Suppression of cirrhosis-related renal injury by N-acetyl cysteine
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چکیده
منابع مشابه
Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury
In this study, using two different injury models in two different species, we found that early post-injury treatment with N-Acetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protocol similar to our recent clinical trial with NAC in blast-induced mTBI in a battlefield setting, to mild concussion from blunt trauma. This study us...
متن کاملCorrection: Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury
Citation: The PLOS ONE Staff (2014) Correction: Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury. PLoS ONE 9(7): e104353. doi:10.1371/journal.pone.0104353 Published July 28, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any m...
متن کاملSeparation and quantification of N-acetyl-l-cysteine and N-acetyl-cysteine-amide by HPLC with fluorescence detection.
N-acetyl-l-cysteine (NAC) is a well-known antioxidant that is capable of facilitating glutathione (GSH) biosynthesis and replenishing intracellular GSH under oxidatively challenging circumstances. N-acetyl-cysteine-amide (NACA), the amide form of NAC, is a newly designed and synthesized thiol-containing compound which is believed to be more lipophilic and permeable through cell membranes than N...
متن کاملN-acetyl Cysteine N-acetyl Cysteine Inhibits Exercise-induced Lymphocyte Apoptotic Protein Alterations
PURPOSE: To investigate the effect of strenuous exercise and antioxidant administration on proand antiapoptotic protein expression in intestinal lymphocytes. METHODS: Female C57BL/6 mice (N = 52) were randomly assigned to receive N-acetyl cysteine (NAC; 1 g.kg(-1)) or saline (SAL) 30 min before treadmill exercise (EX) for 90 min and 2 degrees slope (30 min at 22 m.min(-1), 30 min at 25 m.min(-1...
متن کاملAcetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.
The increase in cellular and mitochondrial glutathione disulfide (GSSG) levels and the GSSG:GSH ratio after acetaminophen (AAP) overdose suggest the involvement of an oxidant stress in the pathophysiology. However, the initial severe depletion of hepatocellular glutathione makes quantitative assessment of the oxidant stress difficult. Therefore, we tested the hypothesis that oxidant stress prec...
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ژورنال
عنوان ژورنال: Current Research in Pharmacology and Drug Discovery
سال: 2020
ISSN: 2590-2571
DOI: 10.1016/j.crphar.2020.100006